Analysis of Drug Substances in Common Cold Medicines with the PerkinElmer Flexar FX-15 System Equipped with a PDA Detector

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چکیده

The common cold is a frequent upper respiratory tract infection caused by a number of different types of viruses. Common cold affects billions of people worldwide every year; its typical symptoms include a runny nose, nasal congestion and sneezing. Colds can also cause sore throat, cough and headache. Common cold viruses do not respond to antibiotics and there are no known cures. Although the symptoms are normally resolved within ten days, they can cause a great deal of discomfort. Fortunately, these symptoms can be alleviated by the use of over-the-counter medicines. These cold remedies invariably include acetaminophen (a pain reliever and fever reducer), a cough suppressant (antitussive) and a nasal decongestant. Commonly used antitussive and nasal decongestant are dextromethorphan HBr and phenylephrine HCL. Dextromethorphan temporarily relieves cough by decreasing activity in the part of the brain that causes the coughing. Phenylephrine relieves nasal discomfort and sinus congestion by reducing the swelling of blood vessels in the nasal passages. Since they don’t treat the underlying cause of the illness, cold medicines do not necessarily speed the recovery. UHPLC a p p l i c a t i o n n o t e

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تاریخ انتشار 2011